But new medications can help lower cholesterol and improve heart health. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. Zetia belongs to a class of drugs called cholesterol absorption inhibitors. And some may be easily managed, too. We've provided a list of the best at-home tests for. They may have suggestions depending on your weight and health goals. However, 0.3% of people who took Zetia alone experienced joint pain so bothersome that they had to stop treatment. Zetia is meant to be used as a long-term treatment. The autonomic nervous system is in charge of all bodily functions that we don't have to think about, such as: The sympathetic nervous system is part of the autonomic nervous system. tender, swollen glands in neck. Some people with POTS also may have one or more . It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. Dizziness is a rare side effect of taking Zetia. What causes POTS? Treatment is targeted at relieving low blood volume or regulating circulatory problems that may cause the disorder. Some side effects are more common than others. If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. It may take about 2 weeks for your cholesterol levels to improve after you start taking Zetia. Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. Zetia is FDA-approved to treat certain forms of high cholesterol in adults and children. The side effects from Zetia .. muscle weakness, joint pain, upper respiratory infectikns resemble the symptoms of malabsorption of Vitamin A,D, E and K. Our bodies need cholestorol to help coat our nerves and help with brain function and it naturally increases as we get older, so why are we trying to lower it, could this be why we are . Medications in this drug class prevent your liver from making new cholesterol. diarrhea*. POTS is defined by its particular symptoms and an excessive increase in heart rate upon standing. Crestor is part of the statin drug class. Lipitor is an HMG-CoA reductase inhibitor (a "statin" drug) and Zetia is a cholesterol -lowering drug. Forget HDL and LDL. Some people have mild symptoms, while for others it can have a big impact on their everyday lives. Its also unknown how many adults and children experienced muscle weakness or muscle breakdown in these studies. Within 4 to 12 hours of oral administration, a single 10-mg dose of Zetia reaches peak plasma concentrations of 3.4 to 5.5 ng/mL. Learn about side effects, dosage, uses, interactions, and more. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. The generic is considered to be as safe and effective as the original drug. joint pain *. Also, if you have a history of heavy drinking or liver damage, be sure to tell your doctor before you begin taking Zetia. What is considered high cholesterol? The expiration date helps guarantee that the medication is effective during this time. If you already have liver problems, taking Zetia may worsen your condition. Your doctor will likely start you on the typical dosage approved to treat your condition. To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel. Examples of bile acid sequestrants include: Zetia inhibits the intestinal absorption of cholesterol and phytosterols, resulting in a decrease in the transport of intestinal cholesterol to the liver. If you have any questions about eating certain foods while taking Zetia, talk with your doctor. Ezetimibe may cause side effects. Phase IV trials are used to detect adverse drug . Zetia is sometimes used with medications in the statin drug class. Then theyll monitor whether the drug is working for you and whether you experience any side effects. Risk factors for muscle-related problems. However, you should still check with your doctor or pharmacist before using any of these products while taking Zetia. Talk with your doctor about any liver problems you may have and whether its safe for you to take Zetia. This helps prevent others, including children and pets, from taking the drug by accident. For this purpose, Zetia may be used alone or with fenofibrate. You should also look for supplements from reputable manufacturers. This means you should avoid foods that are high in cholesterol and other types of fat. Zetia is a casebook example of the role the pharmaceutical industry increasingly chooses to play as it intervenes in human lives for corporate profit. Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs. If youve had an allergic reaction to Zetia or any of its ingredients, you should not take Zetia. Currently, no medications have been approved by the FDA to treat POTS. But, they can have side effects and might not be right for you. Zetia can cause mild or serious side effects. Zetia is indicated as an adjunct to a low-cholesterol diet for treatment of the following types of hyperlipidemia: For treatment of primary hyperlipidemia, Zetia is indicated to reduce total cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, and apiloprotein B (ApoB). This part of the nervous system controls functions that we don't actively control, such as heart rate, blood pressure, perspiration, and temperature. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Liver problems. These lists contain examples of serious side effects that can occur with Lipitor or with both drugs (when taken individually). The bottom line: Zetia may cause fewer side effects than statins (though some clinicians might dispute that) but Zetia may cause muscle problems and other adverse reactions. This is because it isnt safe to eat grapefruit or drink grapefruit juice while using a statin. Talk with your doctor if you have questions about using Zetia to lower your triglyceride levels. If youre experiencing hair loss while using Zetia, talk with your doctor. In Zetia's clinical studies, these were some of the side effects that occurred more often: pain in the arms or legs. The manufacturer of Zetia hasnt given birth control recommendations for males using the drug. It is not yet clear what are the causes of POTS disease. Memory loss isnt a side effect of Zetia. Rhabdomyolysis can also occur with statin drugs, and you may need to take Zetia with a statin. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. New evidence shows that the drug makers Merck and Schering-Plough have conducted several studies of their popular cholesterol medicine Zetia that raise questions about its risks to the liver, but . It isnt known how often this side effect occurred with Zetia in clinical studies. Zetia hasnt been studied in certain types of dyslipidemia, including Frederickson types I, III, IV, and V. Zetia is taken orally with or without food. Taking Zetia with a statin may cause this side effect. zetia. Allergic reaction. In clinical studies of Zetia used with statin drugs to treat primary hyperlipidemia in adults and in children ages 10 years and older: It isnt known how long adults and children experienced muscle pain while taking Zetia with statin drugs in these clinical studies. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Lipitor to treat. Crossing your legs in front of each other while standing, rocking up and down on your toes. Its FDA-approved to treat certain forms of high cholesterol in adults and in children ages 10 years and older. There arent any herbs or supplements that have been specifically reported to interact with Zetia. Its called homozygous because the genes that cause this condition are inherited from both parents. They may be able to suggest ways to relieve this side effect. This may increase your risk of side effects. Hot and cold spells. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). Cholesterol itself isnt a harmful substance. Zetia may cause mild side effects other than the ones listed above. However, your doctor will check your cholesterol levels about 4 weeks after you start treatment. A decrease in the transport of intestinal cholesterol to the liver reduces stores of hepatic cholesterol. Your doctor might suggest one or more of these: fludrocortisone (helps the kidneys retain sodium) midodrine (causes the blood vessels to tighten) beta blockers (slow down the heart rate). High cholesterol occurs when you have more cholesterol in your blood than your body needs. Grapefruit can prevent the breakdown of statins in your body, which can raise your levels of these drugs and increase your risk of side effects. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia, or a malfunction of the autonomic nervous system. Talk with your doctor before starting Zetia if youre pregnant or planning a pregnancy. In these groups, joint pain occurred in: The length of time that adults and children experienced joint pain while taking Zetia in these clinical studies isnt known. Lipitor is also FDA-approved for the following conditions when used with a low-cholesterol diet: primary dysbetalipoproteinemia in adults (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), liver complications, such as high levels of, Both Zetia and Crestor are FDA-approved to treat the following conditions* when used with a. Crestor is also FDA-approved for the following conditions in adults when used with a low-cholesterol diet: primary dysbetalipoproteinemia (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), pain on the right side of your body, below your ribs, in adults as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin drug), in adults in combination with a fenofibrate, in combination with statins, in people with hepatic disease, in combination with statins, in people with elevated hepatic transaminases, in combination with statins, during pregnancy or in someone planning to become pregnant, in combination with statins, while breastfeeding, in people who have a known allergy to Zetia. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. There arent any foods that have been specifically reported to interact with Zetia. (A drug class is a group of medications that work in a similar way.) Like most drugs, Zetia can cause an allergic reaction in some people. Side effects could occur in children who are breastfed by someone taking a statin drug. Temporary excursions of 59F to 86F (15C to 30C) are allowed. Zetia is sometimes used with medications in the statin drug class. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. Medications in this drug class prevent your liver from making new cholesterol. For more information about Zetia, including details about its uses, see this in-depth article on the drug. Below are examples of these side effects. This active drug is also available as a generic medication. And Zetia hasnt been shown to affect blood sugar levels in clinical studies of people with diabetes and people without diabetes. stuffy nose. They can suggest ways to help relieve your side effects, or they may recommend a different treatment option for you. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Dr. said Zetia was different and would not cause these side effects, so I agreed to try it. Zetia and Lipitor are both brand-name drugs. Total cholesterol levels were reduced by an average of: LDL (bad) cholesterol levels were reduced by an average of: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. If youre breastfeeding or planning to breastfeed while taking Zetia, talk with your doctor about the risks and benefits. This in turn increases clearance of cholesterol from the blood. In fact, researchers have looked into using Zetia to treat hair loss due to a condition called alopecia areata. Its not known if Zetia is safe to take during pregnancy. Both drugs are typically taken once each day. POTS-related fatigue is physical in nature . Ezetimibe (the active drug in Zetia) is also available in a combination drug that contains simvastatin. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. Bock's fainting spells are one of the hallmarks of POTS. shaking and sweating. And your doctor can use this information to adjust your treatment plan if needed. Despite having lower total cholesterol than white people, African Americans are at greater risk of dying from heart disease. If you and your doctor decide that Zetia treatment isnt right for you, you simply wont take any more doses. Primary hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. For more information about how the drug is used, see the Zetia uses section below. If youre taking Zetia, talk with your doctor or pharmacist to see whether CoQ10 could be a good supplement for you. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. muscle pain while taking ezetimibe with a statin. You may also want to check out the online communities at Bezzy. But some people have reported memory loss, confusion, and forgetfulness while taking a statin drug. Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. Sharing this information can help you avoid potential interactions. Its primary metabolic pathway is via hepatic glucuronic conjunction. Zetia has a well-documented safety profile. A large review by the American Heart Association compared studies of CoQ10. yellowing of your skin or the whites of your eyes, ahajournals.org/doi/10.1161/JAHA.118.009835, organon.com/product/usa/pi_circulars/z/zetia/zetia_pi.pdf, Alternatives to Statins for Lowering Cholesterol. A medication timer may be useful, too. It belongs to a class of drugs called cholesterol absorption inhibitors. For information on the effectiveness of Zetia, see the Zetia uses section below. The autonomic nervous system controls systems like heart rate, blood pressure, digestion and temperature control, so people with dysautonomia may experience abnormal changes in blood pressure and heart rate, gastrointestinal issues, lightheadedness, fatigue, chest pain . Zetia is a brand-name prescription drug. pain in your arms or legs. Over time, plant sterols can build up in your blood vessels and raise your risk of heart disease. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Crestor to treat. Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. If your muscle-related side effects dont go away or become severe, tell your doctor right away. All rights reserved. Crestor contains the active drug rosuvastatin. Both drugs are typically taken once each day. It also isnt known how many adults and children experienced joint pain in clinical studies of Zetia used to treat other conditions. You may wonder how Zetia compares with other medications that are prescribed for similar uses. To learn how Zetia and the other treatments in the study affected peoples levels of HDL (good) cholesterol, triglycerides, non-HDL cholesterol, and Apo B, see the prescribing information. If you think youve taken too much of this drug, call your doctor. Dont take an extra dose to make up for your missed dose. To help make sure you dont miss a dose, try setting a reminder on your phone. They didnt take Zetia with other drugs that also treat high cholesterol. Zetia is sometimes used with medications in the statin drug class. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Zetia is a lipid-lowering compound used to treat high cholesterol.Common side effects of ezetimibe include diarrhea, abdominal pain, back pain, joint pain, muscle aches, and sinus infection ().. Serious side effects of ezetimibe include hypersensitivity reactions (including angioedema - swelling of the skin and underlying tissues of the head and neck - that can be life-threatening), skin rash . If you have high cholesterol with hypertension (high blood pressure) or diabetes, youll likely have to take other drugs with Zetia to treat these conditions. * To learn more about this side effect, see the Side effects explained section below. For more information about the effectiveness of Zetia for lowering your triglycerides, see the Zetia uses section above. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. As with most drugs, some people can have an allergic reaction after taking Zetia. Postural Tachycardia Syndrome (PoTS) is an abnormality of the autonomic nervous system (ANS). Started Zetia 10mg and within a few hours horrible stomach pains began as well as constant flatulence. Also, Zetia use may cause increased liver enzyme levels, especially if its taken with a statin drug. The actual price youll pay for any of these drugs depends on your insurance plan, your location, and the pharmacy you use. Using Zetia for high cholesterol. Some people may develop mild or serious side effects during Zetia treatment. It only comes in a strength of 10 milligrams (mg). What foods should I avoid while taking Zetia. Zetias side effects are usually mild, especially if youre taking Zetia alone. Medications in the fibrate drug class may increase the amount of cholesterol thats stored in your gallbladder. In order to diagnose POTS, your doctor will need to measure your heart rate when you are sitting at rest. Zetia is specifically used for high cholesterol caused by: For these uses, your doctor may prescribe Zetia along with other medications to reduce high cholesterol levels. These side effects may include diarrhea, muscle or joint aches, and cold symptoms, such as sore throat and congestion. The underlying cause is not known, although it sometimes follows bedrest after injury or illness. Learn about the drugs dosage, forms, strengths. If you would like to report to the FDA a side effect youve had with Zetia, you can do so through MedWatch. Here are answers to some frequently asked questions about Zetia. Cholesterol is a fatty substance found in the cells of your body. The list below includes factors to consider. Zetia is approved to treat different types of high cholesterol. Homozygous sitosterolemia is a genetic condition caused by a mutation (change) in the genes that control how plant sterols are cleared from your body. Your doctor may prescribe Zetia with a statin drug. Zetia is available as a tablet that you take by mouth. In people with POTS, more blood collects in the lower body when standing upright. This can increase your risk of side effects from either medication. People who may be at higher risk of this side effect include those who: Tell your doctor if any of the above apply to you before starting Zetia treatment. Some may be a better fit for you than others. Youll likely take Zetia once a day. In addition to Goff's specific symptoms, POTS can be associated with neurocognitive impairments or "brain fog"; problems with body temperature regulation; gastroenterological symptoms like nausea, abdominal pain, diarrhea, or constipation; and dark red-blue discoloration of the legs. Zetia may cause serious side effects including: muscle pain, muscle tenderness or weakness, fever, unusual tiredness, and. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). Postural orthostatic tachycardia syndrome (POTS) is a condition that causes a number of symptoms when you transition from lying down to standing up, such as a fast heart rate, dizziness and fatigue. Statins are another type of medication used to lower cholesterol. And taking it with Zetia and a statin likely wont cause any problems. Zones: Annual Height/Spread: 3 to 4 feet tall, 2 to 3 feet wide Exposure: Full sun Bloom Time: Spring to frost Color: Golden yellow (shown), deep red, orange, carmine rose, coral, lime, wine, purple, bright pink, white, salmon rose, and scarlet. . Females who could become pregnant should use birth control while taking Zetia with a statin drug. 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